Dr. Bipin G. Nair Professor & Chair Telephone: +91 476 2896318/ 28 Extn: 3003 Telefax: +91 476 2899722 Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Research Interests

The cutaneous wound healing process is a complex phenomenon characterized by the onset of a series of molecular events with a great degree of cross-talk.  The identification of these different pathways is a matter of great interest for both the characterization of the physiologic abnormalities leading to aberrant skin repair in acquired or inherited wound healing disorders and for the improvement of current pharmacologic processes.

The main objective of the laboratory is to understand the molecular mechanisms involved in impaired diabetic wound healing with the focus on the role of two crucial mediators –Epidermal growth factor (EGF) and Nitric oxide.

Studies are in progress to attempt to elucidate the role of cross-talk if any, between the signaling pathways that are involved in the cellular actions of EGF and Nitric oxide. From these studies, the identification of novel lead molecules involved in regulating the process of wound healing, will also provide useful insight into the molecular mechanisms involved in this process.

Other areas of interest also include the development of biomedical devices like a low-cost automated, programmable diabetic Insulin pump for continuous subcutaneous infusion of insulin, to enable improved control of blood glucose levels in diabetic patients.   This work is part of an interdisciplinary effort involving strong collaborative interactions between the biotechnology, endocrinology and mechanical engineering groups in three campuses of Amrita University.

Publications

1. K.A. Alvi, D.B. Baker, V. Steinecker, M.Hosken, and Bipin G. Nair  (2000)  Identification of Inhibitors of Inducible Nitric Oxide Synthase from Microbial Extracts.  J. Antibiotics 53, 496-501.
2. K.A. Alvi, A.Casey and B.G. Nair (1998)  Pulchellalactam:  A CD45 Protein Tyrosine Phosphatase inhibitor from the marine fungus Corollospora pulchella.  J. Antibiotics 51, 515-517.
3. K.Alvi, Bipin Nair, H.Pu, R. Ursino, C. Gallo, and U.Mocek (1997) Phomacins: Three Novel Antitumor Cytochalasan Constituents Produced by a Phoma sp.  J. Org. Chem. 62, (7) 2148-2151.
4. T.B. Patel, H.Sun, H.Poppleton, B.G. Nair, H.M.Rashed and Y.Yu (1996)  Epidermal growth factor mediated regulation of G-proteins and adenylyl cyclase in cardiac muscle.  Methods in Neurosci.  29, 319-343.
5. B.G. Nair, Y. Yu, H.M.Rashed, H.Sun and T. B. Patel  (1995)  Transforming growth factor 1 modulates adenylyl cyclase signalling elements and epidermal growth factor signaling in cardiomyocytes.  J. Cell. Physiol.  164, 232-239.
6. B.G. Nair, H.M. Rashed and T.B. Patel (1993)   Epidermal growth factor produces inotropic and chronotropic effects in rat hearts by increasing cyclic AMP accumulation.   Growth Factors 8, 41-48.
   
   
   
7. B.G. Nair and T.B. Patel (1993)   Regulation of rat cardiac adenylyl cyclase by EGF:  Role of  EGF receptor  protein tyrosine kinase activity.  Biochem. Pharmacol. 46, 1239-1245.
8. B.G. Nair, L.Steinke, Y. Yu, H.M.Rashed . J.M.Seyer and T.B. Patel (1991)  Increase in the number of atrial natriuretic hormone receptors in regenerating rat liver.  J. Biol.  Chem. 266, 567-573.
9. B. G. Nair, B.Parikh, G. Milligan and T.B. Patel  (1990)  Gsa mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase. J. Biol. Chem. 265, 21317-21322.
10. B.G. Nair, H.M. Rashed and  T.B. Patel (1989)  Epidermal growth factor stimulates rat cardiac adenylate cyclase through a GTP binding regulatory protein.  Biochem. J. 264, 563-571.

Awards and Scholarships:

1. Recipient of Junior Research Fellowship, awarded by Dept of Atomic Energy, Govt. of India, 1982-1983.
   
   
2. Recipient of Senior Research Fellowship, awarded by Dept of Atomic Energy, Govt. of India, 1983-1985.  
   
   
3. Recipient of Post-doctoral Research Fellowship awarded by American Heart Association, Tennessee Affiliate, 1990-1992.
   
   
4. Recipient of Grant-in Aid awarded by American HeartAssociation, Tennessee Affiliate, 1992-1993.  
   
   
5. Recipient of the Cora Louis Carson award for the best ranked grant at the Peer Review of the American Heart Association, Tennessee Affiliate, March 1992.