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Dr. G. Anil Kumar
Associate Professor
Telephone: + 91 476 2896318/28 Ext:3102
Email: soanil@amritapuri.amrita.edu
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Research Interests:
Our laboratory is mainly interested in understanding the molecular mechanisms of exocytosis, endocytosis and the intrinsic transporter activity of GLUT4, an insulin resposnsive facilitated glucose transporter that plays a crucial role in regulating the blood glucose homeostasis. Several studies have clearly linked the importance of GLUT4 in preventing the insulin resistance, the inability of the cell to respond to the normal levels of body insulin and is the hallmark of type 2 diabetes.
Educational background
Ph.D. : Indian Institute of Science, Bangalore
M.Tech. : Anna University, Madras
M.Sc. : Cochin University, Cochin
B.Sc. : Kerala University, Kerala
Publications
1. Barwe SP, Maul RS, Christiansen JJ, Anilkumar G, Cooper CR, Kohn DB,Rajasekaran AK. Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix.
Int J Oncol. 2007 Apr;30(4):899-904.
2. Anilkumar G, Barwe SP, Christiansen JJ, Rajasekaran SA, Kohn DB, Rajasekaran AK. Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature. Microvasc Res. 2006 Jul-Sep;72(1-2):54-61.
3. Srinivasan R, Anilkumar G, Rajeswari H, Ajitkumar P.
Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis. FEMS Microbiol Lett. 2006 Jun;259(1):97-105.
4. Christiansen JJ, Rajasekaran SA, Inge L, Cheng L, Anilkumar G, Bander NH,Rajasekaran AK.
N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy. Mol Cancer Ther. 2005 May;4(5):704-14.
5. Rajasekaran AK, Anilkumar G, Christiansen JJ.
Is prostate-specific membrane antigen a multifunctional protein?
Am J Physiol Cell Physiol. 2005 May;288(5):C975-81. Review.
6. Barwe SP, Anilkumar G, Moon SY, Zheng Y, Whitelegge JP, Rajasekaran SA,Rajasekaran AK. Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell. 2005 Mar;16(3):1082-94.
7. Barwe SP, Anilkumar G, Moon SY, Zheng Y, Whitelegge J, Rajasekaran SA, Rajasekaran AK. Na-K-ATPase, Scaffolding Actin Reorganization Sci. STKE, Vol. 2005, Issue 273, pp. tw81, 1 March 2005.
8. Anilkumar G, Srinivasan R, Ajitkumar P.
Genomic organization and in vivo characterization of proteolytic activity of FtsH of Mycobacterium smegmatis SN2. Microbiology. 2004 Aug;150(Pt 8):2629-39.
9. Rajasekaran SA, Anilkumar G, Oshima E, Bowie JU, Liu H, Heston W, Bander NH, Rajasekaran AK. A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.
Mol Biol Cell. 2003 Dec;14(12):4835-45. Epub 2003 Oct 3.
10. Anilkumar G, Rajasekaran SA, Wang S, Hankinson O, Bander NH, Rajasekaran AK. Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity.
Cancer Res. 2003 May 15;63(10):2645-8.
11. Anilkumar G, Srinivasan R, Anand SP, Ajitkumar P.
Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH. Microbiology. 2001 Mar;147(Pt 3):516-7. No abstract available.
12. Anilkumar G, Chauhan MM, Ajitkumar P. Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv. Gene. 1998 Jul 3;214(1-2):7-11.
13. Ussuf KK, Anilkumar G, Nair PM. Newly synthesized mRNA as a probe for identification of wound responsive gene from potatoes.
Indian J. Biochem. and Biophy. (1995), 32(2): 78.
Awards and Scholarships:
Kerala University gold medal for the first rank in B.Sc. examination. Cochin University gold medal for the first rank in M.Sc. examination.
GATE Fellowship (Percentile Score 98.54) from Human Resources and Development Ministry, Govt. of India.
CSIR Fellowship from Council of Scientific and Industrial Research, Govt. of India.
Dr. K.S. Krishnan Senior Research Fellowship from Department of Atomic Energy, Govt. of India.
Indian Institute of Science Fellowship, Bangalore, India.
Postdoctoral Fellowship, Department of Pathology, UCLA.
Postdoctoral Traineeship Award, Department of Defense, USA
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